additional information, references, links


450 mg tablet
Daily intake: 2 tablets with meal, 4 tablets per day

Active ingredients (daily intake):

Artichoke extract 480 mg
   (Cynarin 12 mg);
Milk Thistle extract 240 mg
   (Silymarin 192 mg);
Schisandra Chinensis extract 200 mg
   (Schisandrins 18 mg);
Reishi 400 mg
   (extract 40 mg, Polysaccharides 12 mg);
Maitake 800 mg
   (extract 80 mg, Polysaccharides 16 mg);
Shiitake 400 mg
   (extract 40 mg, Polysaccharides 12 mg);
Siberian Ginseng (Eleuthero) 960 mg
   (extract 240 mg, Eleutherosides 1.92 mg)

(Cynara cardunculus)

Milk thistle
(Silybum marianum)

(Schisandra chinensis)

(Ganoderma lucidum)

(Lentinula edodes)

(Grifola frondosa)

(Siberian Ginseng


- Chemical-induced liver damage (including industrial chemicals, alcohol and pharmaceutical drugs)
- Damaged liver cells
- Hepatitis
- Cirrhosis 
- Gallbladder dysfunctions 


Artichoke (Cynara cardunculus) has been used as a food and medicinal agent for centuries.
Artichoke has been reported to have significant liver protecting and regenerating effects. Hepatoprotective qualities of artichoke seem to be linked to its antioxidant capacity and the Cynarin content, which is claimed to restore healthy growth and reproduction of liver cells. The antioxidant effect has been further supported by laboratory studies in both human and animal cells.
Milk thistle (Silybum marianum) has been used medicinally for more than 2,000 years, principally for the treatment of hepatic and biliary disorders. A flavonoid complex called Silymarin can be extracted from the seeds of Milk thistle and is believed to be the biologically active component. The terms "Milk thistle" and "Silymarin" are often used interchangeably.
There have been a number of human clinical trials demonstrating the efficacy of Milk thistle as a hepatoprotective agent.
The mechanism of Silymarinís reported hepatoprotective activity includes:
- inhibition of the transport of toxins into the liver cells,
- stabilization of the hepatic cell membranes,
- stimulation of new liver cell regeneration through increased protein synthesis,
- selective inhibition of leukotriene formation by Kupffer cells
- inhibition of membrane peroxidation
Silymarin has been demonstrated to increase glutathione content in the liver by more than 35 percent, increasing its antioxidant capacity.
Multiple animal and in vitro studies support its hepatoprotective and antioxidant properties of Schisandra (Schisandra chinensis). The efficacy of Schisandra as a hepatoprotective agent has been demonstrated in multiple animal and in vitro models. Several Schisandraís components possess strong antioxidant activity, acting to enhance the hepatic glutathione antioxidant system by inducing liver microsomal cytochrome P450 and stimulating protein and liver glycogen.
Schisandra extract has been reported to regenerate liver tissue by lowering SGPT levels, a key marker for hepatitis and liver disorders. Based on many observations, Schisandra has been suggested as a potential treatment for liver disease.
Reishi (Ganoderma lucidum) mushroom is called the "mushroom of immortality" in China and has been used as a tonic and strengthening medicine for thousands of years. Uses in traditional healing include increasing intellectual capacity and memory, promoting agility, and lengthening the life span.
Reishi is reported to have some of the most active polysaccharides in the plant kingdom. Polysaccharides are claimed to have immunomodulating activity. Reishi is also reported beneficial as an antioxidant, antihypertensive, hypoglycemic, antiviral, and hepatoprotective agent.
Shiitake mushrooms (Lentinula edodes) are thought to have originated in Japan and China. Secondary sources suggest that Wu Juei, a physician from the Chinese Ming Dynasty (1368-1644), wrote about the ability of shiitake to increase energy, prevent premature aging, cure colds, improve blood circulation, and improve liver health.
Shiitake contains proteins, fats, carbohydrates, soluble fiber, vitamins, and minerals. One main constituent of interest in the fruiting body is the polysaccharide lentinan.
According to laboratory study, shiitake may have a liver protective effect. In vitro, pretreatment of isolated liver cells with an extract of cultured Lentinula edodes mycelia reduced liver cell damage caused by antibody-dependent cell-mediated toxicity or activated macrophage culture supernatants. Based on these study results, the authors suggested that lentinan might have the ability to protect liver cells from immunological damage.
In vitro, extracts of Lentinula edodes mycelia inhibited the morphologic change and proliferation of isolated rat hepatic stellate cells. As these cells play a role in liver fibrosis, the authors suggested that shiitake might be important in the development of hepatoprotective agents.
Maitake protects the liver. Chinese doctors conducted a controlled trial with thirty-two patients who had chronic hepatitis B. The recovery rate was 72 percent in the Maitake treatment group, compared with 57 percent in the control group. Hepatitis antigens disappeared in more than 40 percent of the Maitake patients, indicating the virus had been purged from the liver.
Laboratory studies also show that Maitake protects liver tissue from hepatitis caused by environmental toxins such as carbon tetrachloride and paracematol. These compounds go through a two-step process in the liver in which they are first activated into toxic forms and then deactivated into harmless forms. Since Maitake helps the liver handle chemical poisons in both steps, it protects this organ against a broad range of potential toxins.
Although used in China for several thousand years, this herb was brought to prominence by intensive Russian research in the latter half of the 20th century. In general, Siberian ginseng is completely nontoxic, and Russian investigators have reported on use of exceptionally large doses for up to 20 years with no adverse reactions.
In the traditional Chinese pharmacopoeia, Siberian Ginseng (Wu Jia Pi) is recommended as a liver and kidney tonic. Siberian ginseng has been found to be strongly anti-hepatotoxic and hepatoprotective in vivo against CC14-induced hepatotoxicity.
Siberian ginseng was found to be a hepato-regenerator, significantly stimulating liver regeneration in animals in which portions of the liver had been surgically removed.


- Against chemical-induced liver damage (including industrial chemicals, alcohol and pharmaceutical drugs)
- For regeneration and healthy growth of liver cells
- For increasing anti-oxidant capabilities of liver cells
- For stabilization of the hepatic cell membranes
- Liver detoxication
- Liver cirrhosis
- Hepatitis
- Gallbladder dysfunctions

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