INGREDIENTS ARE FOUND TO BE BENEFICIAL FOR THE FOLLOWING AILMENTS:
- Chemical-induced liver damage (including industrial chemicals, alcohol and pharmaceutical drugs)
- Damaged liver cells
- Gallbladder dysfunctions
REPORTED PROPERTIES OF INGREDIENTS:
Milk thistle (Silybum marianum) has been used medicinally for more than 2,000 years, principally for the treatment of hepatic and biliary disorders. A flavonoid complex called Silymarin can be extracted from the seeds of Milk thistle and is believed to be the biologically active component. The terms "Milk thistle" and "Silymarin" are often used interchangeably.
There have been a number of human clinical trials demonstrating the efficacy of Milk thistle as a hepatoprotective agent.
The mechanism of Silymarinís reported hepatoprotective activity includes:
- inhibition of the transport of toxins into the liver cells,
- stabilization of the hepatic cell membranes,
- stimulation of new liver cell regeneration through increased protein synthesis,
- selective inhibition of leukotriene formation by Kupffer cells,
- inhibition of membrane peroxidation
Silymarin has been demonstrated to increase glutathione content in the liver by more than 35 percent, increasing its antioxidant capacity.
Reishi (Ganoderma lucidum) mushroom is called the "mushroom of immortality" in China and has been used as a tonic and strengthening medicine for thousands of years. Uses in traditional healing include increasing intellectual capacity and memory, promoting agility, and lengthening the life span.
Reishi is reported to have some of the most active polysaccharides in the plant kingdom. Polysaccharides are claimed to have immunomodulating activity. Reishi is also reported beneficial as an antioxidant, antihypertensive, hypoglycemic, antiviral, and hepatoprotective agent.
Shiitake mushrooms (Lentinula edodes) are thought to have originated in Japan and China. Secondary sources suggest that Wu Juei, a physician from the Chinese Ming Dynasty (1368-1644), wrote about the ability of shiitake to increase energy, prevent premature aging, cure colds, improve blood circulation, and improve liver health.
Shiitake contains proteins, fats, carbohydrates, soluble fiber, vitamins, and minerals. One main constituent of interest in the fruiting body is the polysaccharide lentinan.
According to laboratory study, shiitake may have a liver protective effect. In vitro, pretreatment of isolated liver cells with an extract of cultured Lentinula edodes mycelia reduced liver cell damage caused by antibody-dependent cell-mediated toxicity or activated macrophage culture supernatants. Based on these study results, the authors suggested that lentinan might have the ability to protect liver cells from immunological damage.
In vitro, extracts of Lentinula edodes mycelia inhibited the morphologic change and proliferation of isolated rat hepatic stellate cells. As these cells play a role in liver fibrosis, the authors suggested that shiitake might be important in the development of hepatoprotective agents.
Maitake protects the liver. Chinese doctors conducted a controlled trial with thirty-two patients who had chronic hepatitis B. The recovery rate was 72 percent in the Maitake treatment group, compared with 57 percent in the control group. Hepatitis antigens disappeared in more than 40 percent of the Maitake patients, indicating the virus had been purged from the liver.
Laboratory studies also show that Maitake protects liver tissue from hepatitis caused by environmental toxins such as carbon tetrachloride and paracematol. These compounds go through a two-step process in the liver in which they are first activated into toxic forms and then deactivated into harmless forms. Since Maitake helps the liver handle chemical poisons in both steps, it protects this organ against a broad range of potential toxins.
Although used in China for several thousand years, this herb was brought to prominence by intensive Russian research in the latter half of the 20th century. In general, Siberian ginseng is completely nontoxic, and Russian investigators have reported on use of exceptionally large doses for up to 20 years with no adverse reactions.
In the traditional Chinese pharmacopoeia, Siberian Ginseng (Wu Jia Pi) is recommended as a liver and kidney tonic. Siberian ginseng has been found to be strongly anti-hepatotoxic and hepatoprotective in vivo against CC14-induced hepatotoxicity.
Siberian ginseng was found to be a hepato-regenerator, significantly stimulating liver regeneration in animals in which portions of the liver had been surgically removed.
- Against chemical-induced liver damage (including industrial chemicals, alcohol and pharmaceutical drugs)
- For regeneration and healthy growth of liver cells
- For increasing anti-oxidant capabilities of liver cells
- For stabilization of the hepatic cell membranes
- Liver detoxication
- Gallbladder dysfunctions