VISION

INFORMATION FOR SPECIALISTS

LUTEIN-20

Form:
300 mg tablet
Daily intake: 1 tablet per day (with meal)

Active ingredients (daily intake):

Marigold flower 1000 mg
   (extract 100 mg, Lutein 20 mg, Zeaxanthin 2.5 mg); 
  

 


Marigold flower

REPORTED BENEFITS OF INGREDIENTS:

LUTEIN and ZEAXANTHIN
are the primary carotenoids found in the eye.
Individuals in the top quintile (20%) of Lutein / Zeaxanthin consumption are 50% less likely to develop a cataract compared to individuals in the lower quintile of consumption.
Lutein and Zeaxanthin, like "natural sun glasses", are able to protect the eyes against radiation damage by acting as an optic filter and an antioxidant. Higher intake of Lutein and Zeaxanthin resulted in a 30-40% reduction in the amount of blue light reaching the eye, and represents a substantial protection against the type of damage that leads to macular degeneration.
Numerous studies shown direct connection between Lutein and Zeaxanthin intake and the risk for age-related macular degeneration (ARMD). Studies revealed that retinas of individuals with macular degeneration had substantially lower levels of Zeaxanthin and Lutein. Individuals in the top quintile (20%) of Lutein and Zeaxanthin intake were found to have an 82% lower risk of developing age-related macular degeneration compared to individuals in the bottom quintile.
It was found that higher levels of Lutein and Zeaxanthin in the diet were associated with lower rates of pigmentary abnormalities. The results of clinical trials conducted for 120-140 days were maintained for 40-50 days after discontinuing the supplementation.

Precautions / Warnings/ Contraindications / Pregnancy & Lactation / Drug Interactions / Herb and Supplements Interactions
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External links:

LUTEIN, ZEAXANTHIN
Wikipedia, the free encyclopedia: http://en.wikipedia.org/wiki/Lutein
Wikipedia, the free encyclopedia: http://en.wikipedia.org/wiki/Zeaxanthin
U.S. National Library of Medicine National Institutes of Health: http://www.ncbi.nlm.nih.gov/pubmed/15640510
American Optometric Association: http://www.aoa.org/x11815.xml
Lutein Information Bureau: http://www.luteininfo.com/
Macular Degeneration Support: http://www.mdsupport.org/

References:
1. Berendschot TT, Goldbohm RA, Klopping WA, van de Kraats J, van Norel J, van Norren D. Influence of lutein supplementation on macular pigment, assessed with two objective techniques. Invest Ophthalmol Vis Sci. Oct2000;41(11):3322-6.
2. Richer S, Stiles W, Statkute L, et al. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry. Apr2004;75(4):216-30.
3. Cooper DA, Eldridge AL, Peters JC. Dietary carotenoids and certain cancers, heart disease, and age-related macular degeneration: a review of recent research. Nutr Rev. Jul1999;57(7):201-14.
4. Yeum KJ, et al. Measurement of Carotenoids, Retinoids, and Tocopherols in Human Lenses. Invest Ophthalmol Vis Sci. Dec1995;36(13):2756-61.
5. Lyle BJ, et al. Antioxidant Intake and Risk of Incident Age-related Nuclear Cataracts in the Beaver Dam Eye Study. Am J Epidemiol. May1999;149(9):801-09.
6. Pauleikhoff D, van Kuijk FJ, Bird AC. Macular pigment and age-related macular degeneration. Ophthalmologe. Jun2001;98(6):511-9.
7. Nussbaum JJ, et al. Historic Perspectives. Macular Yellow Pigment. The First 200 Years. Retina. 1981;1(4):296-310.
8. Landrum JT, et al. A One Year Study of the Macular Pigment: The Effect of 140 Days of a Lutein Supplement. Exp Eye Res. Jul1997;65(1):57-62.
9. Hammond BR Jr, et al. Dietary Modification of Human Macular Pigment Density. Invest Ophthalmol Vis Sci. Aug1997;38(9):1795-801.
10. Mares-Perlman JA, Fisher AI, Klein R, Palta M, Block G, Millen AE, Wright JD. Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey. Am J Epidemiol. Mar2001;153(5):424-32.
11. Aleman TS, Duncan JL, Bieber ML, de Castro E, Marks DA, Gardner LM, et al. Macular pigment and lutein supplementation in retinitis pigmentosa and Usher syndrome. Invest Ophthalmol Vis Sci. Jul2001;42(8):1873-81.
12. Dagnelie G, Zorge IS, McDonald TM. Lutein improves visual function in some patients with retinal degeneration: a pilot study via the Internet. Optometry. Mar2000;71(3):147-64.
13. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr. Oct1999;70(4):517-24.
14. Lyle BJ, Mares-Perlman JA, Klein BE, et al. Antioxidant intake and risk of incident age-related nuclear cataracts in the Beaver Dam Eye Study. Am J Epidemiol. May1999;149(9):801-9.
15. Moeller SM, Jacques PF, Blumberg JB. The potential role of dietary xanthophylls in cataract and age-related macular degeneration. J Am Coll Nutr. Oct2000;19(5 Suppl):522S-527S.
16. Mares-Perlman JA, Fisher AI, Klein R, Palta M, Block G, Millen AE, Wright JD. Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey. Am J Epidemiol. Mar2001;153(5):424-32.

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